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Systemic Diseases Caused by Oral Infection

Xiaojing Li,1* Kristin M. Kolltveit,1 Leif Tronstad,2 and Ingar OlsenDepartment of Oral Biology1 and Department of Endodontics,2  Faculty of Dentistry, University of Oslo, Oslo, Norway.

Summary: The theory of focal infection, which was promulgated during the 19th and early 20th centuries, stated that “foci” of sepsis were responsible for the initiation and progression of a variety of inflammatory diseases such as arthritis, peptic ulcers, and appendicitis (120). In the oral cavity, therapeutic edentulation was common as a result of the popularity of the focal infection theory.  However, A number of epidemiological studies have suggested that oral infection, especially marginal and apical periodontitis, may be a risk factor for systemic diseases.

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