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There is Always Something New to Discover

Do you know what the most extraordinary thing about science is? No matter how much you study something — there’s always more to discover.

I’ve spent decades investigating the effects of mitochondria — the tiny generators that power every cell in your body — on your energy, health, and longevity. So I was thrilled this week to see a brand new discovery linking mitochondria to a powerful enzyme called NAD+.

According to this new research, increasing the amount of NAD+ in your body can actually help reverse the effect of aging on your muscles.1

How Does it Work?

Well, one reason you can start to feel weaker and more easily tired as you age is a buildup of “broken” proteins that have been folded incorrectly inside your muscles. Over time, this protein buildup starts to damage the mitochondria inside your muscle cells — so you feel less energy, less strength, and more fatigue.2

But NAD+ can activate the natural “defense system” called autophagy inside your mitochondria, to clean up and recycle misfolded proteins so your mitochondria can get back to doing what they do best…Providing you with the youthful energy you need to feel strong and ready to tackle every day.

To me, the most amazing — and exciting — thing about this discovery is…We didn’t know it a month ago. But now that we DO know it, we can take advantage of it!

So you’re probably wondering — How can I get more NAD+? One of the best ways to raise your body’s NAD+ levels is through exercise. But there’s also an easier way…Because NAD+ is actually produced as a byproduct of another important process.

NAD+ has a “sister enzyme” — NADH — that your mitochondria use to produce energy. And after they create that energy, NAD+ is the “leftovers.” I’ll say that again — when your cells use NADH to produce energy…You get that muscle-boosting NAD+ as a side effect!

Aren’t our bodies incredible? By using one powerful compound, you can actually create another powerful compound. So it won’t surprise you to hear that in my opinion…NADH is a fantastic way to boost your NAD+. (Especially if you’re already limited in your ability to exercise.)

With NADH you’re not just fighting the effects of aging muscles…You’re getting a surge of natural mitochondrial energy from NAD+. After age 40, the number of mitochondria in your body takes a sharp nosedive...Causing your cellular energy levels to plummet — and lead to problems like:

  • Not having the same “get up and go” you used to
  • Feeling sluggish or drowsy in the afternoon Trouble starting or finishing projects
  • Cognitive fatigue and mental “cobwebs”

To your longevity,

Dr. Rand McClain

Chief Medical Officer


  1. Ecole Polytechnique Fédérale de Lausanne. (2021, January 20). NAD+ can restore age-related muscle deterioration, research finds. ScienceDaily. Retrieved January 22, 2021 from
  2. Ibid.
  3. Harris C, Chowanadisai W, Mishchuk D, Satre M, Slupsky C, Rucker R. Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. J Nutr Biochem. 2013;24(12):2076-2084. doi:10.1016/j.jnutbio.2013.07.008
  4. Ungvari, Z., Sonntag, W. E., de Cabo, R., Baur, J. A., & Csiszar, A. (2011). Mitochondrial protection by resveratrol. Exercise and sport sciences reviews, 39(3), 128–132.
  5. Imai S, Guarente L. It takes two to tango: NAD+ and sirtuins in aging/longevity control. NPJ Aging Mech Dis. 2016;2(1). doi:10.1038/npjamd.2016.17
  6. Anton SD, Embry C, Marsiske M, et al. Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study. Exp Gerontol. 2014;57:181-7
  7. Sawmiller D, Li S, Mori T, et al. Beneficial effects of a pyrroloquinolinequinone-containing dietary formulation on motor deficiency, cognitive decline and mitochondrial dysfunction in a mouse model of Alzheimer’s disease. Heliyon. 2017;3(4):e00279. Published 2017 Apr 4. doi:10.1016/j.heliyon.2017.e00279
  8. Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014;24(8):464-71